Hebei youze Biotechnology Co.,Ltd(expird)
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Business Type:Trading Company
CAS NO.77-52-1
High(1-50)KilogramHigh(51-500)Kilogram
Our Advantage
1.Best quality with competitive price.
2.Quick shipping,delivery on time.
3.We have a pharmaceutical raw material production plant and a reagent R&D center.
4.Support multiple trading methods and payment.We support wire transfer, , Paypal or escrow payment.
5.One to one business communication.
6.OEM/ODM Avaliable.
7.We offer convenient one-station purchasing service. Our professionaland thoughtful after-sales service eliminates your worries.
8.We has many years exporting experience in active pharmaceutical ingredient products.,Strictly on selecting raw materials.
Quick Details
| Common Name | Ursolic Acid | ||
|---|---|---|---|
| CAS Number | 77-52-1 | Molecular Weight | 456.700 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 556.9±50.0 °C at 760 mmHg |
| Molecular Formula | C30H48O3 | Melting Point | 292 °C (dec.)(lit.) |
| MSDS | ChineseUSA | Flash Point | 304.7±26.6 °C |
Ursolic acid(Bungeolic acid) is a natural pentacyclic triterpenoid carboxylic acid, exerts anti-tumor effects and is an effective compound for cancer prevention and therapy. IC50 value:Target:in vitro: UA induced phosphorylation of AMP-activated protein kinase alpha (AMPKα) and suppressed the protein expression of DNA methyltransferase 1 (DNMT1) in the dose-dependent manner [1]. The combination of ursolic acid (0.5 μM) and leucine (10 μM) proved to be the most effective in promoting myogenic differentiation. The combination of ursolic acid and leucine significantly increased CK activity than treatment with either agent alone. The level of myosin heavy chain, a myogenic differentiation marker protein, was also enhanced by the combination of ursolic acid and leucine [2]. Ursolic acid efficiently induced apoptosis, possibly via the downregulation of B-cell lymphoma 2 (Bcl-2), the upregulation of Bcl-2-associated X protein and the proteolytic activation of caspase-3. Furthermore, the activation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase was increased by the administration of ursolic acid. In addition, ursolic acid significantly suppressed the invasive phenotype of the SNU-484 cells and significantly decreased the expression of matrix metalloproteinase (MMP)-2 [3]. ursolic acid (UA) potently induces the apoptosis of gastric cancer SGC-7901 cells. Further mechanistic studies revealed that the ROCK1/PTEN signaling pathway plays a critical role in UA-mediated mitochondrial translocation of cofilin-1 and apoptosis [4].in vivo: UA treatment markedly improved the survival of septic rats, and attenuated CLP-induced lung injury, including reduction of lung wet/dry weight ratio, infiltration of leukocytes and proteins, myeloperoxidase activity, and malondialdehyde content. In addition, UA significantly decreased the serum levels of tumor necrosis factor-α, interleukin-6, and interleukin-1β, inhibited the expression of inducible nitric oxide synthase and cyclooxygenase-2 in the lung, which are involved in the productions of nitric oxide and prostaglandin E2 [5].
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Our Company Profile
Hebei Youze Biological Technology Co., Ltd. has a registered capital of 1 million yuan and is one of the most dynamic foreign trade companies in the Chinese market. We have a pharmaceutical raw material production plant and a reagent R&D center. We now have the most complete product line. In addition, we have developed and produced tens of thousands of reagents. We also have the business of custom synthesis of various organic compounds as a supplement. We can synthesize almost all chemicals. Our goal is to survive by quality and develop by credit.
In the past two years, our products have spread over more than 30 countries in the world, Europe, South America, North America, Southeast Asia and Africa. We work with friends all over the world to develop the best quality products, the most reasonable prices and safe and effective transportation. Product can be ordered from milligrams to tons. Meet the purchase of new and old customers. We will not let you down.
Quality Best, Customer First" is what we adhering all the time, we have enjoyed a high reputation in the world market, mainly North America, Eastern Europe, Western Europe, South America, and Southeast Asia.....United States,Canada,UnitedKingdom,Holland,Poland,Australia,India,Netherlands,Germany,New zealand,Ireland,Russia,Kazakhstan,south africa and so on, all these countriese have our customers.
"Fast shipment, safety delivery" is our advantage. We successfully shipped many Raw materials, API, Steriods, and so on, to many countries in the world. Good feedback and repeat orders surport both our company and customers's development.
We are warmly welcome your visit, and test our quality and channel.