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Hebei youze Biotechnology Co.,Ltd(expird)

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Hebei youze Biotechnology Co.,Ltd(expird)

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Year Established:
2022
Home>>Products>>Gliclazide BP CAS 21187-98-4 1-(hexahydrocyclopenta(c)pyrrol-2(1h)-yl)-3-(p-tolylsulfonyl)-ure

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Hebei youze Biotechnology Co.,Ltd(expird)

Country: China (Mainland)

Business Type:Trading Company

Gliclazide BP CAS 21187-98-4 1-(hexahydrocyclopenta(c)pyrrol-2(1h)-yl)-3-(p-tolylsulfonyl)-ure

CAS NO.21187-98-4

  • FOB Price: USD: 6.80-8.60 /Kilogram Get Latest Price
  • Min.Order: 1 Kilogram
  • Payment Terms: D/A,D/P,T/T,Other
  • Available Specifications:

    High(1-50)KilogramHigh(51-500)Kilogram

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Product Details

Keywords

  • Gliclazide
  • 21187-98-4
  • 1-(hexahydrocyclopenta(c)pyrrol-2(1h)-yl)-3-(p-tolylsulfonyl)-ure

Quick Details

  • ProName: Gliclazide BP CAS 21187-98-4 1-(hexahy...
  • CasNo: 21187-98-4
  • Molecular Formula: C15H21N3O3S
  • Appearance: White crystalline powder
  • Application: Pharmaceutical Intermediates
  • DeliveryTime: Usually within 3-5 working days after ...
  • PackAge: Customized
  • Port: TianJin, Shanghai, Qingdao
  • ProductionCapacity: 2000 Metric Ton/Month
  • Purity: 99%
  • Storage: Sealed, cool and dry storage
  • Transportation: ShippingBY EMS, DHL, TNT, UPS, FEDEX O...
  • LimitNum: 1 Kilogram
  • Moisture Content: N/A
  • Impurity: N/A
  • N/A: N/A

Superiority

Our Advantage

1.Best quality with competitive price.

2.Quick shipping,delivery on time.

3.We have a pharmaceutical raw material production plant and a reagent R&D center.

4.Support multiple trading methods and payment.We support wire transfer, , Paypal or escrow  payment.

5.One to one business communication.

6.OEM/ODM Avaliable.

7.We offer convenient one-station purchasing service. Our professionaland thoughtful after-sales service eliminates your worries.

8.We has many years exporting experience in active pharmaceutical ingredient products.,Strictly on selecting raw materials.

Details

Quick Details 

Common Name Gliclazide
CAS Number 21187-98-4 Molecular Weight 323.410
Density 1.4±0.1 g/cm3        Boiling Point N/A
Molecular Formula C15H21N3O3S Melting Point 163-169 °C(lit.)       
MSDS ChineseUSA Flash Point N/A

Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.Target: Potassium Channelgliclazide further characterize its mechanism of hypoglycemic effect: the observed improvements in insulin sensitivity and in GLUT4 translocation indicate that gliclazide counters the hydrogen peroxide-induced insulin resistance in 3T3L1 adipocytes and also would further augment the hypoglycemic effect of this drug as insulinotropic sulfonylurea [1]. Gliclazide blocked whole-cell beta-cell KATP currents with an IC50 of 184 +/- 30 nmol/l (n = 6-10) but was much less effective in cardiac and smooth muscle (IC50s of 19.5 +/- 5.4 micromol/l (n = 6-12) and 37.9 +/- 1.0 micromol/l (n = 5-10), respectively). In all three tissues, the action of the drug on whole-cell KATP currents was rapidly reversible. In inside-out patches on beta-cells, gliclazide (1 micromol/l) produced a maximum of 66 +/- 13 % inhibition (n = 5), compared with more than 98 % block in the whole-cell configuration. Gliclazide is a high-potency sulphonylurea which shows specificity for the pancreatic beta-cell KATP channel over heart and smooth muscle. In this respect, it differs from glibenclamide [2].
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Packaging & Delivery

Delivery Detail: Usually within 3-5 working days after full payment.

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Our Company Profile 

Hebei Youze Biological Technology Co., Ltd. has a registered capital of 1 million yuan and is one of the most dynamic foreign trade companies in the Chinese market. We have a pharmaceutical raw material production plant and a reagent R&D center. We now have the most complete product line. In addition, we have developed and produced tens of thousands of reagents. We also have the business of custom synthesis of various organic compounds as a supplement. We can synthesize almost all chemicals. Our goal is to survive by quality and develop by credit.

In the past two years, our products have spread over more than 30 countries in the world, Europe, South America, North America, Southeast Asia and Africa. We work with friends all over the world to develop the best quality products, the most reasonable prices and safe and effective transportation. Product can be ordered from milligrams to tons. Meet the purchase of new and old customers. We will not let you down.

Quality Best, Customer First" is what we adhering all the time, we have enjoyed a high reputation in the world market, mainly North America, Eastern Europe, Western Europe, South America,  and Southeast Asia.....United States,Canada,UnitedKingdom,Holland,Poland,Australia,India,Netherlands,Germany,New zealand,Ireland,Russia,Kazakhstan,south africa and so on, all these countriese have our customers. 

"Fast shipment, safety delivery" is our advantage. We successfully shipped many Raw materials, API, Steriods, and so on, to many countries in the world. Good feedback and repeat orders surport both our company and customers's development.

We are warmly welcome your visit, and test our quality and channel.

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