Keywords

• Purchase Tadalafil
• Cialis Good Producer
• Tadalafil In Medicine

Quick Details

• ProName: Offer High Quality Tadalafil 171596-29...
• CasNo: 171596-29-5
• Molecular Formula: C22H19N3O4
• Appearance: Grayish white crystalline solid
• Application: Tadalafil is a PDE5 inhibitor with an ...
• DeliveryTime: 3-5 days after payment received
• PackAge: Aluminum foil bag/fluorinated bottle/d...
• Port: Shanghai, Wuhan, Qingdao, Guangzhou
• ProductionCapacity: 1000 Metric Ton/Day
• Purity: 99%
• Storage: Hygroscopic, -20?C Freezer, Under Iner...
• Transportation: EMS, DHL, TNT, UPS, FEDEX, BY AIR, BY ...
• LimitNum: 1 Kilogram

Superiority

Quick Details

Offer High Quality Tadalafil 171596-29-5 Global Supply

• ProName:Tadalafil 
• CasNo:171596-29-5
• Molecular Formula:C₂₂H₁₉N₃O₄
• Melting Point:298-300ºC
• Boiling Point:679.1±55.0 °C at 760 mmHg
• Refractive index:1.758
• Flash Point:364.5±31.5 °C
• Purity: 99%
• Density:1.5±0.1 g/cm3
• PSA:74.87000
• LogP:1.43
• Appearance：Grayish white crystalline solid
• Storage conditions：Hygroscopic, -20 C Freezer, Under Inert Atmosphere
• Packaging Detail:customized
• Payment Term:  T/T or L/C, D/P, DIA, WU, MG
• Delivery Detail: Usually within 3-5 working days after full payment 
• Shipping: EMS, DHL, TNT, UPS, FEDEX, BY AIR, BY SEA

Tadalafil 171596-29-5 Various preparation methods：

1. TADALAFIL HAVING A LARGE PARTICLE SIZE AND A PROCESS FOR PREPARATION THEREOF The present invention provides particulate tadalafil having a particle size of about 200 to about 600 microns and a process for controlling the particle size of tadalafil.

2. Alternative synthesis of tadalafil: PDE5 inhibitor Two-step alternative synthesis of tadalafil (1) is described. The synthesis features Pictet-Spengeler type reaction and DCC (N,N′- dicyclohexylcarbodiimide)/HOBt (N-hydroxybenzotriazole)-mediated double amidation employing sarcosine ethyl ester hydrochlor

3. Compound acyl intermediate as well as synthetic method thereof and application thereof in preparing tadalafil

The invention discloses a compound acyl intermediate as well as a synthetic method and application thereof in preparing tadalafil. The synthetic method comprises the following steps: preparing (1R, 3R)-methyl-1-(3,4-dihydroxyphenyl)-2,3,4,9-tetrahydro-1H-pyridino[3,4-b]indol-3-carboxylic acid (compound I) by taking D-tryptophan methyl ester hydrochloride and 3,4-dihydroxy benzaldehyde as raw materials, and allowing the compound I to have chloroacetylation with chloroacetyl chloride to generate the compound acyl intermediate. By adopting the method, raw materials are easy to get, so that the technical weakness caused by using the poisonable chemical controlled by the public security department in the prior art as a raw material is overcome. The preparation process requires no catalyst, and the yield is high. The obtained compound acyl intermediate can be used for preparing the tadalafil, and is simple and easy, stable in process, low in cost, and suitable for industrialized mass production. The structural formula of the compound acyl intermediate is shown as formula (II): (see the description) (II).

4.Novel synthetic method for tadalafil The invention relates to a synthetic method for a compound in the technical field of medicine and chemical engineering, and particularly relates to a novel synthetic method for tadalafil. The synthetic method comprises the steps of: 1) condensing an initial raw material which is D-tryptophan (I) and methylamino acetonitrile (II) or salt thereof to obtain a compound as shown in a formula III; 2) carrying out Pictet-Spengler cyclization reaction on the compound as shown in the formula III and carrying out crystallization to obtain a compound as shown in a formula V; and 3) hydrolyzing the compound V under an acidic or alkaline condition by cyano and then condensing the compound to obtain the target product tadalafil (VI). The formula is shown in the description. In the synthetic method provided by the invention, chemical raw materials which are great in toxicity, severe in environmental pollution and flammable and combustible such as thionyl chloride, chloroacetyl chloride, the like. The novel synthetic method for tadalafil provided by the invention is simple in reaction method, convenient to operate and high in yield.

Details

Tadalafil (market name “Cialis” or “Adcirca”) is a kind of PDE5 inhibitor used for the treatment of erectile dysfunction, benign prostatic hypertrophy and pulmonary arterial hypertension. The effect of Tadalafil is relaxing the blood vessels muscles and increasing the blood flow into the corpus cavernosum. The mechanism of action of tadalafil is through inhibiting the activity of the cGMP specific phosphodiesterase type 5 (PDE5). PDE5 degrades cGMP in the corpus cavernosum located around the penis. Therefore, tadalafi leads to the increased concentration of cGMP which further causes the smooth muscle relaxation and increased blood flow into the corpus cavernosum. Some clinical studies also implied that tadalafil could improve endothelia function in men with increased cardiovascular risk and lower the urinary tract symptoms secondary to benign prostatic hyperplasia.

Packaging & Delivery

Packaging Detail: customized

Payment Term:  T/T or L/C, D/P, DIA, WU, MG

Delivery Detail: Usually within 3-5 working days after full payment Shipping: EMS, DHL, TNT, UPS, FEDEX, BY AIR, BY SEA

Our Company

Hebei Youze Biological Technology Co., Ltd. has a registered capital of 1 million yuan and is one of the most dynamic foreign trade companies in the Chinese market. We have a pharmaceutical raw material production plant and a reagent R&D center. We now have the most complete product line. In addition, we have developed and produced tens of thousands of reagents. We also have the business of custom synthesis of various organic compounds as a supplement. We can synthesize almost all chemicals. Our goal is to survive by quality and develop by credit.

In the past two years, our products have spread over more than 30 countries in the world, Europe, South America, North America, Southeast Asia and Africa. We work with friends all over the world to develop the best quality products, the most reasonable prices and safe and effective transportation. Product can be ordered from milligrams to tons. Meet the purchase of new and old customers. We will not let you down.

1: Fast and guaranteed shipment (TNT;EMS;FEDEX;DHL;UPS;EUB, special line)
2: Various payment terms accepted (Btc;MoneyGram;WU)
3: Valued package (Paraffin coating; Double aluminum foil bag; Vacuum packaging)
4: Efficient delivery (3-10 DAYS fast delivery service )
5: Best quality (Without any doping, all the products are pure)
6: Good reputation (we have been in this industry for years, earned great trust from our clients from allover the world)
7: Huge Capacity (We have plenty manufactue centers, each day can produce  tons of various products)
8: The most competitive price (manufacture and produce by our own factories).

9. In the end, we have the most professional experienced and dedicated team here.